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2019 Vol.32, Issue 2 Preview Page

Research Article

Effect of the Extracts from the Leaves and Branches of Sageretia thea on β-catenin Proteasomal Degradation in Human Colorectal and Lung Cancer Cells

상동나무(Sageretia thea) 잎과 가지추출물의 대장암과 폐암세포의 β-catenin 분해 유도 활성

Kim Ha Na1
,
Gwang Hun Park2
,
Jeong Dong Kim1
,
Su Bin Park1
,
Hyun Ji Eo3
,
Jin Boo Jeong4*
김 하나1
,
박 광훈2
,
김 정동1
,
박 수빈1
,
어 현지3
,
정 진부4*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립산림과학원 산림약용자원연구소, 연구사
3국립산림과학원 산림약용자원연구소, 박사후연구원
4국립안동대학교 생약자원학과, 교수
* Corresponding Author
30 April 2019. pp. 153-159
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Abstract

In this study, we evaluated the effect of branch (STB) and leave (STL) extracts from Sageretia thea on β-catenin level in human colorecal cancer cells, SW480 and lung cancer cells, A549. STB and STL dose-dependently suppressed the growth of SW480 and A549 cells. STB and STL decreased β-catenin level in both protein and mRNA level. MG132 decreased the downregulation of β-catenin protein level induced by STB and STL. However, the inhibition of GSK3β by LiCl or ROS scavenging by NAC did not block the reduction of β-catenin protein by STB and STL. Our results suggested that STB and STL may downregulate β-catenin protein level independent on GSK3β and ROS. Based on these findings, STB and STL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer and lung cancer.

Keywords
Anticancer activity
β-catenin
Cancer chemoprevention
Sageretia thea
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 32
  • No :2
  • Pages :153-159
  • Received Date : 2019-03-06
  • Revised Date : 2019-04-16
  • Accepted Date : 2019-04-18
  • DOI :https://doi.org/10.7732/kjpr.2019.32.2.153
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