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2018 Vol.31, Issue 3 Preview Page

Research Article

Anti-Inflammatory Effect of the Root extracts from Hibiscus syriacus in LPS-Stimulated RAW264.7 Cells
Ha Na Kim1
,
Su Bin Park1
,
Gwang Hun Park2
,
Hyun Ji Eo2
,
Jeong Ho Song2
,
Hae Yun Kwon3
,
Jin Boo Jeong14*
1Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Forest Tree Improvement Division, Forest Bioresources Department, National Institute of Forest Research, Suwon 16631, Korea
4Agricultural Science and Technology Research Institute, Andong National University, Andong 36729, Korea
* Corresponding Author
30 June 2018. pp. 211-217
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Abstract

Hibiscus syriacus (H. syriacus) as the national flower of Korea has been used as the herbal medicine in Asia. In this study, we evaluated the anti-inflammatory effect of 70% ethanol extracts from the root of Hibiscus syriacus (RHS-E70) and elucidated the potential signaling pathway in LPS-stimulated RAW264.7 cells. RHS-E70 dose-dependently suppressed NO production by inhibiting iNOS and IL-β expression in LPS-stimulated RAW264.7 cells. RHS-E70 inhibited the phosphorylation and degradation of IκB-α, which contributed to the inhibition of p65 nuclear accumulation and NF-κB activation. Furthermore, RHS-E70 suppressed the phosphorylation of ERK1/2 and p38, which results in the inhibition of ATF2 phosphorylation and subsequent nuclear accumulation. These results indicate that RHS-E70 may exert anti- inflammatory activity by inhibiting NF-κB and MAPK/ATF2 signaling. From these findings, RHS-E70 has potential to be a candidate for the development of chemopreventive or therapeutic agents for the inflammatory diseases.

Keywords
Anti-inflammatory effect
Hibiscus syriacus
MAPK
NF-κB
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :3
  • Pages :211-217
  • Received Date : 2018-05-09
  • Revised Date : 2018-06-13
  • Accepted Date : 2018-06-13
  • DOI :https://doi.org/10.7732/kjpr.2018.31.3.211
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