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2020 Vol.33, Issue 5 Preview Page

Research Article

Vasodilatation Effect of Kirenol Isolated from Sigesbeckia pubescens

털진득찰에서 분리한 Kirenol의 혈관 이완효과

Jung Hwan Nam1*
남 정환1*
1Researcher, Highland Agriculture Research Institute, National Institute of Crop Science, Rural Development Administration, Pyeongchang 25342, Korea
1농촌진흥청 국립식량과학원 고령지농업연구소, 농업연구사
* Corresponding Author
1 October 2020. pp. 467-475
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Abstract

The purpose of this study is to investigate the vasodilatation effect of kirenol isolated from Sigesbeckia pubescens on the rabbit basilar artery. In this study, to determine the vasodilatation effect of kirenol on the rabbit basilar artery, arterial rings with intact or damaged endothelium were used for the experiment. And used an organ bath and force transducer were contracted by endothelin. Kirenol, major active constituents of S. pubescens, showed a moderate vasodilatation effect on the basilar arteries of rabbits. Therefore, treatment with kirenol may selectively accelerate cerebral blood flow through dilatation of the basilar artery. This result suggests a potential role of kirenol isolated from S. pubescens as a source of vasodilatation agent.

Keywords
Basilar artery
Endothelin
Kirenol
Sigesbeckia pubescens
Vasodilatation
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 33
  • No :5
  • Pages :467-475
  • Received Date : 2020-08-05
  • Revised Date : 2020-09-18
  • Accepted Date : 2020-09-23
  • DOI :https://doi.org/10.7732/kjpr.2020.33.5.467
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