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2020 Vol.33, Issue 5 Preview Page

Research Article

Inhibitory Effect of the Rodgersia podophylla Leave Extracts against Cell Proliferation through Activation of NF-κB in Human Colorectal Cancer Cells

도깨비부채 잎 추출물의 NF-κB 활성화를 통한 대장암 세포 HCT116에 대한 세포생육 억제활성

Jeong Dong Kim1
,
Jin Boo Jeong2*
김 정동1
,
정 진부2*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립안동대학교 생약자원학과, 교수
* Corresponding Author
1 October 2020. pp. 460-466
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Abstract

In this study, we evaluated the anti-cancer activity and potential molecular mechanism of 70% ethanol extracts of leaves from Rodgersia podophylla against human colorectal cancer cells, HCT116. RPL dose-dependently decreased the cell viability through RPL-induced apoptosis in HCT116 cells. RPL induced inactivation the nuclear factor κB(NF-κB) through blocking IκB-α degradtion and P65 nuclear accumulation. The inhibition of GSK3β by LiCl attenuated RP-L-mediated NF-κB signaling inactivation. In addition, RP-L induced GSK3β activation. Based on these findings, RPL may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer.

Keywords
Anticancer activity
NF-κB signaling pathway
Rodgersia podophylla
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 33
  • No :5
  • Pages :460-466
  • Received Date : 2020-05-12
  • Revised Date : 2020-09-23
  • Accepted Date : 2020-09-23
  • DOI :https://doi.org/10.7732/kjpr.2020.33.5.460
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