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2018 Vol.31, Issue 5 Preview Page

Research Article

Enhancement of Melanin Synthesis by the Branch Extracts of Vaccinium oldhamii through Activating Tyrosinase Activity in B16F10 Melanoma Cells
Kun Ho Son1*
,
Jueng Kyu Baek2*
,
Su Bin Park2
,
Ha Na Kim2
,
Gwang Hun Park3
,
Ho-Jun Son3
,
Hyun Ji Eo4
,
Jeong Ho Song5
,
Hyung Jin Jeong6
,
Jin Boo Jeong6**
1Professor, Department of Food and Nutrition, Andong National University
2Graduate Student, Department of Medicinal Plant Resources, Andong National University
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science
4Post-doc Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science
5Senior researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science
6Professor, Department of Medicinal Plant Resources, Andong National University
* First Author
** Corresponding Author
31 October 2018. pp. 547-553
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Abstract

This study was conducted to investigate the effect of branch extracts of Vaccinium oldhamii (VOB) on melanin synthesis in B16F10 cells. VOB promoted melanin production in absence or presence of α-melanocyte-stimulating hormone (α-MSH) in B16F10 cells. However, VOB did not affect the expression of tyrosinase and TRP-1 associated with melanin synthesis at the mRNA and protein levels in B16F10. But, VOB decreased TRP-2 protein level and induced tyrosinase activation in B16F10 cells. Inhibition of tyrosinase activity and tyrosinase knockdown attenuated VOB-mediated melanin synthesis. In conclusion, VOB may stimulate melanin synthesis through activating tyrosinase activity.

Keywords
Melanin
Melanogenesis
Tyrosinase activity
Vaccinium oldhamii
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :5
  • Pages :547-553
  • Received Date : 2018-07-24
  • Revised Date : 2018-09-11
  • Accepted Date : 2018-09-18
  • DOI :https://doi.org/10.7732/kjpr.2018.31.5.547
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