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2018 Vol.31, Issue 6 Preview Page

Research Article

Anti-inflammatory Effect of Leaves Extracts from Aralia cordata through Inhibition of NF-κB and MAPKs Signaling in LPS-stimulated RAW264.7 Cells
Eo Hyun Ji1
,
Da Som Kim2
,
Su Jin Sim2
,
Gwang Hun Park3
,
Jeong Ho Song4
,
Jin Boo Jeong5
,
Nahyun Kim3*
1Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science
2Research Fellow, Forest Medicinal Resources Research Center, National Institute of Forest Science
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science
4Senior Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science
5Professor, Department of Medicinal Plant Resources, Andong National University
*Corresponding Author
31 December 2018. pp. 634-640
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Abstract

Aralia cordata (A. cordata), which belongs to Araliaceae, is a perennial herb widely distributed in East Asia. We evaluated the anti-inflammatory effect of stems (AC-S), roots (AC-R) and leaves (AC-L) extracted with 100% methanol of A. cordata and elucidated the potential signaling pathway in LPS-stimulated RAW264.7 cells. The AC-L showed a strong anti-inflammatory activity through inhibition of NO production. AC-L dose-dependently inhibited NO production by suppressing iNOS, COX-2 and IL-β expression in LPS-stimulated RAW264.7 cells. AC-L inhibited the degradation and phosphorylation of IκB-α, which donated to the inhibition of p65 nuclear accumulation and NF-κB activation. Furthermore, AC-L suppressed the phosphorylation of ERK1/2 and p38. These results suggested that AC-L may utilize anti-inflammatory activity by blocking NF-κB and MAPK signaling pathway and indicated that the AC-L can be used as a natural anti-inflammatory drugs.

Keywords
Anti-inflammatory drugs
Aralia cordata
Nitric Oxide
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :6
  • Pages :634-640
  • Received Date : 2018-11-07
  • Revised Date : 2018-12-04
  • Accepted Date : 2018-12-06
  • DOI :https://doi.org/10.7732/kjpr.2018.31.6.634
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