All Issue

2018 Vol.31, Issue 4 Preview Page
Modulative Effect of Human Hair Dermal Papilla Cell Apoptosis by Oregonin from the Braches of Alnus japonica

오리나무 가지 유래 Oregonin의 인체 모유두 세포 Apoptosis 조절 효능

Gyeong Hwa Lee1
Kwang Hyun Park2
Sun Eun Choi1*
이 경화1
박 광현2
최 선은1*
1Department of Cosmetology Science, Nambu University
2Department of Oriental Pharmaceutical Development, Nambu University
1남부대학교 향장미용학과
2남부대학교 한방제약개발학과
* Corresponding Author
August 2018. pp. 322-329
PDF XML
Abstract

A diarylheptanoid, (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5- hydroxyheptane-3-one-5-O-β-D-xylopyranoside, named oregonin (1), was isolated from the of Alnus japonica (A. japonica), which is a species of the genus Betulaceae, growing throughout Korea, Japan and China. The structure was elucidated by various spectroscopic methods including negative and positive LC/MS, 1H-NMR, and 13C-NMR techniques or by comparison with authentic samples. In order to evaluate the anti-oxidative activities of oregonin (1) isolated from A. japonica, 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS) radical scavenging activity were measured in vitro. Oregonin from A. japonica exhibited potent DPPH and ABTS radical scavenging activities. A. japonica shows not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and ABTS radical scavenging activity, but also apoptosis modulative effects. The present results indicate that A. japonica could be a hair-growth-promoting agent for cosmetic products.

Keywords
Alnus japonica
Anti-oxidant
Hair growth
Oregonin
References
1 

Alnemri, E.S., D.J. Livingston, D.W. Nicholson, G. Salvesen, N.A. Thornberry, W.W. Wong and J. Yuan. 1996. Human ICE/CED-3 protease nomenclature. Cell 87:171.

10.1016/S0092-8674(00)81334-3
2 

Alnermri, E.S. 1997. Mammalian cell death proteases: a family of highly conserved aspartate specific cystein proteases. J. Cell. Biochem. 64:32-42.

3 

Boericke, W. 1927. Pocket Manual of Homeopathic Materia Medica with Repertory (Ninth Edition). Boericke & Tafel, INC. Santa Rosa, CA (USA). p. 24.

4 

Boivin, W.A., H. Jiang, O.B. Utting and D.W.C. Hunt. 2006. Influence of interleukin-1α on androgen receptor expression and cytokine secretion by cultured human dermal papilla cells. Exp. Dermatol. 15:784-793.

10.1111/j.1600-0625.2006.00462.x16984260
5 

Burnette, W.N. 1981. Western blotting: electrophoretic transfer of proteins from sodium dodecyl sulfate—polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:195-203.

10.1016/0003-2697(81)90281-5
6 

Choi, S.E. 2013. Chemotaxonomic significance of oregonin in Alnus species. Asian J. Chem. 25:6989.

7 

Choi, S.E. 2013. K.H. Park, M.H. Kim, J.H. Song, H.Y. Jin and M.W. Lee. 2012. Diarylheptanoids from the Bark of Alnus pendula Matsumura. Nat. Prod. Sci. 18:106.

8 

Choi, S.E. 2013. M.S. Jeong, M.J. Kang, D.I. Lee, S.S. Joo, C.S. Lee, H. Bang, M.K. Lee, S.C. Myung, Y.W. Choi, K. Lee, S.J. Seo and M.W. Lee. 2010. Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis in NC/Nga mice. Exp. Dermatol. 19:37-43.

10.1111/j.1600-0625.2009.00961.x19849716
9 

Clarke, P.G. and S. Clarke. 1995. Historic apoptosis. Nature 378:230.

10.1038/378230c07477334
10 

Cleary, M. L., S.D. Smith and J. Sklar. 1986 Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28.

10.1016/0092-8674(86)90362-4
11 

Godon, C., F.P. Cordelieres, D. Biard, N. Giocanti, F. Megnin- Chanet, J. Hall and V. Favaudon. 2008. PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility. Nucleic Acids Res. 36:4454-4464.

10.1093/nar/gkn40318603595PMC2490739
12 

Harrington, H.A., L.K. Ho, S. Ghosh and K.C. Tung. 2008. Construction and analysis of a modular model of caspase activation in apoptosis. Theor. Biol. Med. Model. 5:1-15.

10.1186/1742-4682-5-2619077196PMC2672941
13 

Hatano, T., R. Edamatsu, M. Hiramatsu, A. Mori, Y. Fujita, T. Yasuhara, T. Yoshida and T. Okuda. 1989. Effects of the interaction of tannins with co-existing substances. Ⅵ. Effects of tannins and ralated polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. Chem. Pharm. Bull. 37:2016-2021.

14 

Kim, H.J., K.H. Kim, S.H. Yeom, M.K. Kim, J.G. Shim, H.W. Lim and M.W. Lee. 2005. New diarylheptanoids from the barks of Alnus japonica Steudel, Chin. Chem. Lett. 16:1337-1340.

15 

Lee, S.J. 1966. Korea Folk Medicine. Seoul National University Publishing Center Press, Seoul, Korea. p. 40.

16 

Lim, H.W., M.K. Kim, H.J. Kim, J.G. Shim, G.H. Kim, H.K. Choi and M.W. Lee. 2004. Quantitative determination of diarylheptanoid compounds from Korean Alnus. Kor. J. Pharmacogn. 35:384-387.

17 

Muller, S., J.P. Briand, S. Barakat, J. Lagueux, G.G. Poirier, G. De Murcia and D.A. Isenberg. 1994. Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNA. Clin. Immunol. Immunopathol. 73:187-196.

10.1006/clin.1994.11877923925
18 

Oltvai, Z.N., C.L. Milliman and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619.

10.1016/0092-8674(93)90509-O
19 

Re, R., N. Pellegrini, A. Proteggente, A. Pannala, M. Yang and C. Rice-Evans. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free. Radic. Biol. Med. 26:1231-1237.

10.1016/S0891-5849(98)00315-3
20 

Schultz, N., E. Lopez, N. Saleh-Gohari and T. Helleday. 2003. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res. 31:4959-4964.

10.1093/nar/gkg70312930944PMC212803
21 

Sedlak, T.W., Z.N. Oltvai, E. Yang, K. Wang, L.H. Boise, C.B. Thompson and S.J. Korsmeyer. 1995. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. PNASU. 92:7834-7838.

10.1073/pnas.92.17.7834
22 

Tsujimoto, Y., L.R. Finger, J. Yunis, P.C. Nowell and C.M. Croce. 1984. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099.

10.1126/science.60932636093263
23 

Xie, G.H., S.E. Choi, M.J. Mun, J.H. Jeong and K.H. Park. 2018. Ameliorative effects of combinative injection of Ginko biloba leaves extract and vitamin C on ischemia/ reperfusion liver damages model. Korean J. Plant Res. 31:268-273.

24 

Zhap, Z.Q., J.M. Budde, C. Morris, N.P. Wang, D.A. Velez, S. Murak, R.A. Guyton and J.J. Vinten. 2001. Adenosine attenuated reperfusion induced apoptotic cell death by modulation expression of Bcl-2 and Bax proteins. J. Mol. Cell Cardiol. 33:57-68.

10.1006/jmcc.2000.127511133223
Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :4
  • Pages :322-329
  • Received Date :2018. 02. 08
  • Revised Date :2018. 04. 16
  • Accepted Date : 2018. 05. 18
  • DOI :https://doi.org/10.7732/kjpr.2018.31.4.322
Journal Informaiton Korean Journal of Plant Resources Korean Journal of Plant Resources
  • NRF
  • KOFST
  • crosscheck
  • orcid
  • KISTI Cited-by
  • ccl
  • KISTI Current Status
Journal Informaiton Journal Informaiton - close