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2018 Vol.31, Issue 4 Preview Page

Research Article

Modulative Effect of Human Hair Dermal Papilla Cell Apoptosis by Oregonin from the Braches of Alnus japonica

오리나무 가지 유래 Oregonin의 인체 모유두 세포 Apoptosis 조절 효능

Gyeong Hwa Lee1
Kwang Hyun Park2
Sun Eun Choi1*
이 경화1
박 광현2
최 선은1*
1Department of Cosmetology Science, Nambu University
2Department of Oriental Pharmaceutical Development, Nambu University
1남부대학교 향장미용학과
2남부대학교 한방제약개발학과
* Corresponding Author
August 2018. pp. 322-329
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Abstract

A diarylheptanoid, (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5- hydroxyheptane-3-one-5-O-β-D-xylopyranoside, named oregonin (1), was isolated from the of Alnus japonica (A. japonica), which is a species of the genus Betulaceae, growing throughout Korea, Japan and China. The structure was elucidated by various spectroscopic methods including negative and positive LC/MS, 1H-NMR, and 13C-NMR techniques or by comparison with authentic samples. In order to evaluate the anti-oxidative activities of oregonin (1) isolated from A. japonica, 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis[3-ethylbenzothiazoline-6-sulphonic acid] (ABTS) radical scavenging activity were measured in vitro. Oregonin from A. japonica exhibited potent DPPH and ABTS radical scavenging activities. A. japonica shows not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and ABTS radical scavenging activity, but also apoptosis modulative effects. The present results indicate that A. japonica could be a hair-growth-promoting agent for cosmetic products.

Keywords
Alnus japonica
Anti-oxidant
Hair growth
Oregonin
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 31
  • No :4
  • Pages :322-329
  • Received Date :2018. 02. 08
  • Revised Date :2018. 04. 16
  • Accepted Date : 2018. 05. 18
  • DOI :https://doi.org/10.7732/kjpr.2018.31.4.322
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