Oldenlandia diffusa Ameliorates on Atopic Dermatitis in Mice

Mi-Ok Yang; Noh-Yil Myung

doi:10.7732/kjpr.2023.36.6.556

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2023 Vol.36, Issue 6 Preview Page Next Page

Research Article

Oldenlandia diffusa Ameliorates on Atopic Dermatitis in Mice

1 December 2023. pp. 556-561

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Abstract

Oldenlandia diffusa (OD), a member of the Rubiaceae family, has been used for treating inflammatory and infectious diseases. However, the anti-atopic effects of OD are not completely understood yet. Thus, the aim of the present study was to elucidate beneficial effects of OD on atopic dermatitis (AD) in vivo. We examined the pharmacological effects of OD on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlrobenzene (DNCB)-induced AD-like skin lesions in mice. Additionally, we evaluated regulatory effects of OD on the expression of interleukin (IL)-6 and tumor necrosis factor (TNF)–α in DNCB-induced AD-like skin lesions. Results showed that OD inhibited the scratching behavior and AD symptoms. It also decreased serum levels of IgE and histamine in mice. Moreover, OD significantly ameliorated the expression of IL-6 and TNF–α in AD-like skin lesion. These finding suggest experimental evidence of that OD’s potential for treating AD.

Keywords

Atopic dermatitis

Inflammatory cytokine

Oldenlandia diffusa

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Information

Publisher :The Plant Resources Society of Korea
Publisher(Ko) :한국자원식물학회
Journal Title :Korean Journal of Plant Resources
Journal Title(Ko) :한국자원식물학회지
Volume : 36
No :6
Pages :556-561
Received Date : 2023-10-29
Revised Date : 2023-11-02
Accepted Date : 2023-11-07
DOI :https://doi.org/10.7732/kjpr.2023.36.6.556

Korean Journal of Plant Resources 한국자원식물학회지 ISSN:1226-3591(Print) 2287-8203(Online)

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