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2019 Vol.32, Issue 4 Preview Page

Research Article

Effect of Ainsliaea acerifolia Extract on Anti-acetylcholinesterase and Peroxynitrite Scavenging and Analysis of Caffeoylquinic Acids

단풍취 추출물의 Acetylcholinesterase 저해 및 Peroxynitrite 소거에 대한 활성과 Caffeoylquinic Acid 성분의 분석

Agung Nugroho1
,
Jae Sue Choi2
,
Byong-Min Song3
,
Hee-Juhn Park4*
누그로호 아궁1
,
최 재수2
,
송 병민3
,
박 희준4*
1Professor, Department of Agro-industrial Technology, Lambung Mangkurat University, Banjarbaru 70714, Indonesia
2Professor, Department of Food and Nutrition, Pukyung National University, Busan 48513, Korea
3Professor, Department of Forest Science, Sangji University, Wonju 26339, Korea
4Professor, Department of Pharmaceutical Engineering, Sangji University, Wonju 26339, Korea
1람붕망쿠라트대학교 식품공학과, 교수
2부경대학교 식품영양학과, 교수
3상지대학교 산림과학과, 교수
4상지대학교 제약공학과, 교수
* Corresponding Author
31 August 2019. pp. 270-274
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Abstract

Anti-acetylcholinesterase (anti-AChE) activity and peroxynitrite scavenging activity of Ainsliaea acerifolia (Compositae) were studied to find its anti-Alzheimer’activity. The IC50 was 73.4 ㎍/mL in AChE assay and 8.60 ㎍/mL in peroxynitrite assay. Caffeoylquinic acids that have been reported to have anti-Alzheimer’s activity were analyzed in the leaf- and stem extract by HPLC. Caffeoylquinic acids occupied 25.1% of the leaf extract which was higher than 8.1% of the stem extract. Particularly, the content of 3,5-dicaffeoylquinic acid (145.6 ㎎/g) was highest of the tested caffeoylquinic acids. In addition, the IC50 values of 3,5-dicaffeoylquinic acid were shown to be 3.79 ㎍/mL in peroxynitrite assay and 69.19 ㎍/mL in anti-AChE assay.

Keywords
Acetylcholinesterase
Ainsliaea acerifolia
Alzheimer’s disease
Caffeoylquinic acid
Compositae
Peroxynitrite
References
1
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2
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3
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5
Han, J., Y. Miyamae, H. Shigemori and H. Isoda. 2010. Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neurosci. 169: 1039-1045.
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Kooy, N.W., J.A. Royall, H. Ischiropoulos and J.S. Beckman. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med. 16:149-156.
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8
Kwon, S.H., H.K. Lee, J.A. Kim, S.I. Hong, H.C. Kim, T.H. Jo, Y.I. Park, C.K. Lee, Y.B. Kim, S.Y. Lee and C.G. Jang. 2010. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-cholinesterase and anti- oxidative activities in mice. Eur. J. Pharmacol. 649:210-217.
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Lai, T.S., W.F. Wang, B.S. Yip, Y.W. Yang, G.S. Peng, S.J. Tsai, Y.C. Liao and M.C. Pai. 2016. Real-world evaluation of compliance and preference in Alzheimer's disease treatment: an observational study in Taiwan. Patient Pref. Adherence 10:383-390.
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Patcher, P., I.G. Obrosova, J.G. Mabley and C. Szabó. 2005. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr. Med. Chem. 12:267-275.
10.2174/092986705336320715723618PMC2225483
1
Choi, J.S., B.M. Song and H.J. Park. 2017. Identification of the component with anti-acetylcholinesterase activity from the essential oil of Artemisia iwayomogi. Korean J. Plant Res. 30:17-21 (in Korean).
10.7732/kjpr.2016.30.1.017
2
Choi, R.J., A. Roy, H.J. Jung, M.Y. Ali, B.S. Min, C.H. Park, T. Yokozawa, T.P. Fan, J.S. Choi and H.A. Jung. 2016. BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides. J. Ethnopharmacol. 190:219-230.
10.1016/j.jep.2016.06.01327275774
3
Ellman, G.L., D. Courtney and K.D.V. Andres. 1961. Featherstone R.M., A new and rapid colorimetric activity. Biochem. Pharmacol. 7:88-95.
10.1016/0006-2952(61)90145-9
4
Georgiev, M., K. Alipieva, I. Orhan, R. Abrashev, P. Denev. and M. Angelova. 2011. Antioxidant and cholinesterases inhibitory activities of Verbascum xanthophoeniceum Griseb. and its phenylethanoid glycosides. Food Chem. 128:100-105.
10.1016/j.foodchem.2011.02.08325214335
5
Han, J., Y. Miyamae, H. Shigemori and H. Isoda. 2010. Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neurosci. 169: 1039-1045.
10.1016/j.neuroscience.2010.05.04920570715
6
Kim, T.J. 1996. Korean Resources Plants. 1996. Department of Seoul National University, Seoul, Korea. p. 215.
7
Kooy, N.W., J.A. Royall, H. Ischiropoulos and J.S. Beckman. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radic. Biol. Med. 16:149-156.
10.1016/0891-5849(94)90138-4
8
Kwon, S.H., H.K. Lee, J.A. Kim, S.I. Hong, H.C. Kim, T.H. Jo, Y.I. Park, C.K. Lee, Y.B. Kim, S.Y. Lee and C.G. Jang. 2010. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-cholinesterase and anti- oxidative activities in mice. Eur. J. Pharmacol. 649:210-217.
10.1016/j.ejphar.2010.09.00120854806
9
Lai, T.S., W.F. Wang, B.S. Yip, Y.W. Yang, G.S. Peng, S.J. Tsai, Y.C. Liao and M.C. Pai. 2016. Real-world evaluation of compliance and preference in Alzheimer's disease treatment: an observational study in Taiwan. Patient Pref. Adherence 10:383-390.
10.2147/PPA.S9527127099476PMC4821393
10
Patcher, P., I.G. Obrosova, J.G. Mabley and C. Szabó. 2005. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies. Curr. Med. Chem. 12:267-275.
10.2174/092986705336320715723618PMC2225483
Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 32
  • No :4
  • Pages :270-274
  • Received Date : 2019-04-25
  • Revised Date : 2019-06-15
  • Accepted Date : 2019-07-23
  • DOI :https://doi.org/10.7732/kjpr.2019.32.4.270
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