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2020 Vol.33, Issue 4 Preview Page

Research Article

Inhibitory Activity of Lonicera caerulea Against Cell Proliferation in Human Colorectal Cancer Cells

댕댕이나무(Lonicera caerulea)의 대장암세포 생육억제 활성

Mi-Yun An1†
,
Hyun Ji Eo2†
,
Ho-Jun Son3
,
Gwang Hun Park3
,
Jin Boo Jeong4*
안 미연1†
,
어 현지2†
,
손 호준3
,
박 광훈3
,
정 진부4*
1Graduate Student, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
2Post-doc, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
3Researcher, Forest Medicinal Resources Research Center, National Institute of Forest Science, Yeongju 36040, Korea
4Professor, Department of Medicinal Plant Resources, Andong National University, Andong 36729, Korea
1국립안동대학교 생약자원학과, 대학원생
2국립산림과학원 산림약용자원연구소, 박사후연구원
3국립산림과학원 산림약용자원연구소, 연구사
4국립안동대학교 생약자원학과, 교수
* Corresponding Author
† These authors contributed equally to this work.
1 August 2020. pp. 263-270
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Abstract

In this study, we evaluated the effect of the extracts from Lonicera caerulea leaves (LCLE), branches (LCBE) and fruits (LCFE) on the cell growth and migration in human colorectal cancer cells, HCT116 and SW480 cells. LCLE and LCBE dose- and time-dependently inhibited the proliferation of HCT116 and SW480 cells. However, LCFE did not affect the proliferation of HCT116 and SW480 cells. In addition, LCLE and LCBE dramatically cell migration and wound healing in HCT116 cells. LCLE and LCBE decreased β-catenin protein level but not mRNA level in HCT116 and SW480 cells. Furthermore, LCLE decreased TCF4 level in both protein and mRNA level in HCT116 and SW480 cells. However, LCBE decreased TCF4 protein level but not mRNA level in HCT116 and SW480 cells. Based on these findings, LCLE and LCBE may inhibit the cell proliferation and migration through blocking Wnt signaling activation in human colorectal cancer cells. Therefore, LCLE and LCBE may be a potential candidate for the development of chemopreventive or therapeutic agents for human colorectal cancer.

Keywords
Anticancer activity
β-Catenin
Lonicera caerulea
TCF4
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Information
  • Publisher :The Plant Resources Society of Korea
  • Publisher(Ko) :한국자원식물학회
  • Journal Title :Korean Journal of Plant Resources
  • Journal Title(Ko) :한국자원식물학회지
  • Volume : 33
  • No :4
  • Pages :263-270
  • Received Date : 2020-03-30
  • Revised Date : 2020-05-12
  • Accepted Date : 2020-05-14
  • DOI :https://doi.org/10.7732/kjpr.2020.33.4.263
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